Science FDA (and everyone else) needs to actively engage as they think about whether to authorize Juul and the other ecigs

When I read the FDA’s Technical Project Lead summary of its scientific justification for authorizing the sale of RJ Reynolds’ Vuse Solo e-cigarette, I was struck by the fact that it ignored the broad scientific literature on e-cigarettes and seemed to accept industry-framed arguments. For example: They ignored the evidence that as consumer products, e-cigarettesContinue reading “Science FDA (and everyone else) needs to actively engage as they think about whether to authorize Juul and the other ecigs”

E-cigs have been on the market for 15 years: If they were really reducing harm it would be obvious by now

Ever since e-cigarettes first came on the market in 2006 the argument has been that it will take time for their health benefits to be manifest. This view was restated again last month in an FDA press release that stated, “Companies who want to continue to market their flavored ENDS products must have robust andContinue reading “E-cigs have been on the market for 15 years: If they were really reducing harm it would be obvious by now”

IQOS emissions create risks of immunosuppression and pulmonary toxicity and the supplemental modified risk tobacco product application for IQOS 3 does not address new published research on these risks, so FDA should not issue an exposure modification MRTP order for IQOS 3

My colleagues and I at the UCSF TCORS submitted this public comment to the FDA. The Regulations.gov tracking number is kt4-u9mw-wc65. A PDF version is available here. IQOS emissions create risks of immunosuppression and pulmonary toxicity and the supplemental modified risk tobacco product application for IQOS 3 does not address new published research on theseContinue reading “IQOS emissions create risks of immunosuppression and pulmonary toxicity and the supplemental modified risk tobacco product application for IQOS 3 does not address new published research on these risks, so FDA should not issue an exposure modification MRTP order for IQOS 3”

New WHO report highlights falling cigarette use and challenges that new tobacco products pose to public health and implementation of the FCTC

On July 27, 2021 the WHO released the WHO report on the global tobacco epidemic 2021: addressing new and emerging products, its eighth such report. The good news is that it documents solid progress in reducing tobacco use. After over a century of growth, “between 2007 and 2019, smoking rates decreased from a global averageContinue reading “New WHO report highlights falling cigarette use and challenges that new tobacco products pose to public health and implementation of the FCTC”

“The Devil’s Playbook” is a great read

My definition of a good book on tobacco is that I learn things I didn’t already know from reading it. Lauren Etter’s new book, The Devil’s Playbook, easily meets and surpasses this standard. Deeply researched beginning with key events in the 1980s, she documents the rise and decline on Juul e-cigarettes and how, at leastContinue reading ““The Devil’s Playbook” is a great read”

We know a lot about how e-cigarettes cause disease

The evidence on the health effects of e-cigarettes was the subject of two recently published reviews that focus on cardiovascular, pulmonary and immunologic effects of e-cigarettes. These reviews complement earlier reviews on the pulmonary effects of e-cigarettes, e-cigarettes and smoking cessation, and the gateway effect for smoking among youth and young adults. Taken together theseContinue reading “We know a lot about how e-cigarettes cause disease”

More evidence that dual use is worse than smoking

Krisha Reddy and colleagues just published “ Respiratory Symptom Incidence Among People Using Electronic Cigarettes, Combustible Tobacco, or Both” in American Journal of Respiratory and Critical Care Medicine that showed that dual use of e-cigarettes and cigarettes doubled the odds of developing respiratory symptoms (aOR 2.22, 95% CI 1.79-2.75). This was a statistically significantly biggerContinue reading “More evidence that dual use is worse than smoking”

E-cig use associated with asthma, COPD in never-smokers

One of the excuses that e-cigarette advocates have used to dismiss the papers linking e-cigarette use with lung disease — that most e-cigarette users are current or former smokers — just got blown away with publication of a new study by Emine Bircan and colleagues of the association between e-cigarette use and lung disease inContinue reading “E-cig use associated with asthma, COPD in never-smokers”

The biological evidence of e-cig dangers keeps piling up

Rachel Keith and Aruni Bhatnagar just published “Cardiorespiratory and Immunologic Effects of Electronic Cigarettes,” which is a nice overview of the growing biological evidence base that e-cigarettes have a lot of adverse health effects, many similar to cigarettes. This material is particularly important because the people who continue to promote e-cigarettes for “harm reduction” continueContinue reading “The biological evidence of e-cig dangers keeps piling up”