E-cig science has marched on; it is important that decision making and education be based on the current state of knowledge

In January 2021, I published a blog post making the point that the 2018 National Academy of Science Engineering and Medicine (NASEM) report on e-cigarettes was out of date. Now, Physicians for a Smoke Free Canada has published an extensive update detailing specifically how the science on e-cigarettes has advanced since then 2018, noting thatContinue reading “E-cig science has marched on; it is important that decision making and education be based on the current state of knowledge”

A wide range of e-cigarettes similarly harm artery function as much as cigarettes

The whole harm reduction and reduced exposure frameworks that the FDA and others use to assess alternative inhaled tobacco products assumes that the specific details of the aerosol that these products deliver to users has a substantial effect on risks. New research by Poonam Rao, Matt Springer, and their colleagues at UCSF raises serious questionsContinue reading “A wide range of e-cigarettes similarly harm artery function as much as cigarettes”

Ecig use associated with about double the odds of erectile dysfunction

Cigarette smoking causes erectile dysfunction, a point highlighted in the California Tobacco Control Program’s 1998 ad, “Gala Event” (below). There are multiple pathways between smoking and erectile dysfunction, including adverse effects of nicotine, depression in testosterone, increased risk of cardiovascular and other disease and adverse effects on the ability of arteries to dilate (get larger).Continue reading “Ecig use associated with about double the odds of erectile dysfunction”

World Heart Federation highlights cardiovascular risks of e-cigs, calls for strict regulation, supports countries with bans

On October 18, 2021 the World Heart Federation released a policy brief “E-cigarettes: A new threat to cardiovascular health,” (press release) that provides an overview of the evidence that e-cigarette use has a wide range of adverse effects on the cardiovascular system that are reflected as an increased risk of heart attack at a populationContinue reading “World Heart Federation highlights cardiovascular risks of e-cigs, calls for strict regulation, supports countries with bans”

Science FDA (and everyone else) needs to actively engage as they think about whether to authorize Juul and the other ecigs

When I read the FDA’s Technical Project Lead summary of its scientific justification for authorizing the sale of RJ Reynolds’ Vuse Solo e-cigarette, I was struck by the fact that it ignored the broad scientific literature on e-cigarettes and seemed to accept industry-framed arguments. For example: They ignored the evidence that as consumer products, e-cigarettesContinue reading “Science FDA (and everyone else) needs to actively engage as they think about whether to authorize Juul and the other ecigs”

E-cigs have been on the market for 15 years: If they were really reducing harm it would be obvious by now

Ever since e-cigarettes first came on the market in 2006 the argument has been that it will take time for their health benefits to be manifest. This view was restated again last month in an FDA press release that stated, “Companies who want to continue to market their flavored ENDS products must have robust andContinue reading “E-cigs have been on the market for 15 years: If they were really reducing harm it would be obvious by now”

PMPSA’s supplemental modified risk tobacco product application for IQOS 3 does not support the conclusion that IQOS will not harm vascular endothelial function and does not address new published research, so FDA should not issue an exposure modification MRTP order for IQOS 3 support the conclusion that IQOS will not harm vascular endothelial function and does not address new published research, so FDA should not issue an exposure modification MRTP order for IQOS 3

My colleagues and I at the UCSF TCORS just submitted this public comment to the FDA. The tracking number on Regulations.gov is kta-aq6w-3tph. A PDF is available here. PMPSA’s supplemental modified risk tobacco product application for IQOS 3 does not support the conclusion that IQOS will not harm vascular endothelial function and does not addressContinue reading “PMPSA’s supplemental modified risk tobacco product application for IQOS 3 does not support the conclusion that IQOS will not harm vascular endothelial function and does not address new published research, so FDA should not issue an exposure modification MRTP order for IQOS 3 support the conclusion that IQOS will not harm vascular endothelial function and does not address new published research, so FDA should not issue an exposure modification MRTP order for IQOS 3”

New WHO report highlights falling cigarette use and challenges that new tobacco products pose to public health and implementation of the FCTC

On July 27, 2021 the WHO released the WHO report on the global tobacco epidemic 2021: addressing new and emerging products, its eighth such report. The good news is that it documents solid progress in reducing tobacco use. After over a century of growth, “between 2007 and 2019, smoking rates decreased from a global averageContinue reading “New WHO report highlights falling cigarette use and challenges that new tobacco products pose to public health and implementation of the FCTC”

We know a lot about how e-cigarettes cause disease

The evidence on the health effects of e-cigarettes was the subject of two recently published reviews that focus on cardiovascular, pulmonary and immunologic effects of e-cigarettes. These reviews complement earlier reviews on the pulmonary effects of e-cigarettes, e-cigarettes and smoking cessation, and the gateway effect for smoking among youth and young adults. Taken together theseContinue reading “We know a lot about how e-cigarettes cause disease”

The biological evidence of e-cig dangers keeps piling up

Rachel Keith and Aruni Bhatnagar just published “Cardiorespiratory and Immunologic Effects of Electronic Cigarettes,” which is a nice overview of the growing biological evidence base that e-cigarettes have a lot of adverse health effects, many similar to cigarettes. This material is particularly important because the people who continue to promote e-cigarettes for “harm reduction” continueContinue reading “The biological evidence of e-cig dangers keeps piling up”