Three year study finds that fourth-generation e-cigarettes like Juul associated with continued smoking and vaping

Most studies of the association between e-cigarette use and smoking and nicotine cessation have been conducted with the earlier generation e-cigarettes, which do not deliver nicotine as effectively as the fourth generation e-cigarettes pioneered by Juul. (These e-cigarettes use protonated nicotine [also called nicotine salts] to increase nicotine delivery to the user.) Our meta-analysis ofContinue reading “Three year study finds that fourth-generation e-cigarettes like Juul associated with continued smoking and vaping”

Historical and political context for Philip Morris International’s continuing medical education courses on harm reduction: Implications for current product regulation

In mid-2024 Drs. Robert Jackler, Pam Ling and others learned that the for-profit medical company Medcape was offering a continuing medical education course on tobacco harm reduction sponsored by Philip Morris International that promoted the industry position that smokers could reduce risk by switching from cigarettes to “less risky” products, such as smokeless tobacco. MostContinue reading “Historical and political context for Philip Morris International’s continuing medical education courses on harm reduction: Implications for current product regulation”

Heated tobacco products increase risk of metabolic syndrome more than smoking

The tobacco companies have been aggressively promoting heated tobacco products (HTP), including Philip Morris IQOS, BAT’s glo and JTI’s Ploom, as safer alternatives to cigarettes as part of the companies’ efforts to reposition themselves as “part of the solution” to the tobacco problem. Similar to e-cigarettes, they argue that these products are safer because theContinue reading “Heated tobacco products increase risk of metabolic syndrome more than smoking”

Dual use is not an intermediate condition on the way from cigarettes to “switching completely” or quitting

Discussion of potential harm reduction associated with the use of e-cigarettes assumes that smokers will “switch completely” from cigarettes to e-cigarettes or stop both tobacco products. Advocates of this view, including the US FDA, recognize and accept that this process may include a period of dual use in which smokers use both products. Now JosefContinue reading “Dual use is not an intermediate condition on the way from cigarettes to “switching completely” or quitting”

Dual cigarette and e-cig use increases human risk of lung cancer 40 times

As summarized in an earlier blog post, exposure to e-cigarette aerosol accelerates tumore growth and spread (metastasis) among established cancers. This effect is distinct from actually causing the cancer (i.e., carcinogenesis). Indeed, propylene glycol and vegetable glycerine (PG/VG), the primary solvents in e-liquid and which have been assumed to be inert are major causes ofContinue reading “Dual cigarette and e-cig use increases human risk of lung cancer 40 times”

E-cig advocates publish results showing e-cig users have more respiratory symptoms than nonsmokers

E-cigarette advocate Riccardo Polosa, along with pro-harm reduction colleagues from around the world, recently published Respiratory symptoms among e-cigarette users without an established smoking history in the VERITAS cohort. Their paper presents strong evidence that sole e-cigarette users (i.e., people who are not also smoking cigarettes) are significantly more likely to experience respiratory symptoms thanContinue reading “E-cig advocates publish results showing e-cig users have more respiratory symptoms than nonsmokers”

FDA & NIH must support research to increase tobacco cessation reach and engagement to address populations disproportionately harmed by Big Tobacco

My colleagues and I submitted this public commento to FDA and NIH regarding their priorities for tobacco cessatio research. The Regulations.gov tracking number is m3p-2qiq-zm6w. A PDF version is available here. While it was not publicly available when we were preparing this comment, a lot of the suggestions overlap or complement the recently-released Surgeon GeneralContinue reading “FDA & NIH must support research to increase tobacco cessation reach and engagement to address populations disproportionately harmed by Big Tobacco”

The RCP got this right: Promotion of tobacco harm reduction is playing right into the tobacco industry’s hands

I previously published three detailed critiques of the 2024 UK Royal College of Physicians report E-cigarettes and Harm Reduction: An Evidence Review for being an incomplete and selective review of the literature in three areas — underestimating the magnitude of disease risk caused by e-cigarettes, ignoring the large body of real world evidence that e-cigarettesContinue reading “The RCP got this right: Promotion of tobacco harm reduction is playing right into the tobacco industry’s hands”

Smokers who use e-cigs as for smoking cessation are more likely to end up dual users than to “switch completely” or stop smoking and vaping

E-cigarette enthusiasts, including the FDA and the NHS and others in England, and some in New Zealand and Canadian governments continue to promote “switching completely” from cigarettes to e-cigarettes as a form of harm reduction. I just found another paper that shows that the reality is that adult smokers who use e-cigarettes as a smokingContinue reading “Smokers who use e-cigs as for smoking cessation are more likely to end up dual users than to “switch completely” or stop smoking and vaping”

Calif updates state ban on sales of flavored tobacco products to close loophole and strengthen enforcement: A great model for others

When California passed its law prohibiting the sale of flavored tobacco products in 2020, including menthol cigarettes, RJR and other tobacco interests forced a referendum to try and block the law. Voters upheld the law in 2022, and it went into effect. This law prohibited retail sales of tobacco products with a “characterizing flavor,” looselyContinue reading “Calif updates state ban on sales of flavored tobacco products to close loophole and strengthen enforcement: A great model for others”